1-(4,4-Bis(4-fluorophenyl)butyl)piperazine → HCID 67340165, compound

HRID 1674782Notes

Reaction equation

HRID 1674782 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:4][CH:3]=1.Cl[C:26]1[CH:27]=[CH:28][C:29]2[N:30]([C:32]([C:35]([F:38])([F:37])[F:36])=[N:33][N:34]=2)[N:31]=1>>[F:24][C:21]1[CH:20]=[CH:19][C:18]([CH:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[CH2:9][CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([C:26]3[CH:27]=[CH:28][C:29]4[N:30]([C:32]([C:35]([F:36])([F:38])[F:37])=[N:33][N:34]=4)[N:31]=3)[CH2:16][CH2:17]2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 797291-(4,4-Bis(4-fluorophenyl)butyl)piperazineHCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine

Product 1

HCID 67340165HCID 67340165, compound

Procedure

A mixture of 1-[4,4-bis(4-fluorophenyl)butyl]piperazine and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 3. The crude product was purified by hplc using a Waters XTerra C18 column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give 6-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.

Workup

  1. customto react by General Synthetic Method 3
  2. customThe crude product was purified by hplc
  3. washeluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents

Sources & evidence

ORD record
ord-9c89b04cfedd4beb809457ae1e7c535f
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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