6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → HCID 67340791, compound

HRID 1674789Notes

Reaction equation

HRID 1674789 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:5][CH:4]=1.Cl[C:23]1[CH:24]=[CH:25][C:26]2[N:27]([C:29]([C:32]([F:35])([F:34])[F:33])=[N:30][N:31]=2)[N:28]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]2[CH2:11][CH2:12][N:13]([C:23]3[CH:24]=[CH:25][C:26]4[N:27]([C:29]([C:32]([F:33])([F:35])[F:34])=[N:30][N:31]=4)[N:28]=3)[CH2:14][CH2:15]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazineHCID 31498161-[(4-methoxyphenyl)-phenylmethyl]piperazine

Product 1

HCID 67340791HCID 67340791, compound

Procedure

A mixture of 1-[(4-methoxyphenyl)-phenylmethyl]piperazine and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 3. The crude product was purified by hplc using a Waters XTerra C18 column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give 6-[4-[(4-methoxyphenyl)-phenylmethyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.

Workup

  1. customto react by General Synthetic Method 3
  2. customThe crude product was purified by hplc
  3. washeluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents

Sources & evidence

ORD record
ord-40f23c48f5834aaf9dfa198a361f5d09
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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