6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → HCID 86638060, compound

HRID 1674790Notes

Reaction equation

HRID 1674790 reaction equation
[C:1]1([CH:7]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:25]1[CH:26]=[CH:27][C:28]2[N:29]([C:31]([C:34]([F:37])([F:36])[F:35])=[N:32][N:33]=2)[N:30]=1>>[C:1]1([CH:7]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[N:8]2[CH2:9][CH2:10][N:11]([C:25]3[CH:26]=[CH:27][C:28]4[N:29]([C:31]([C:34]([F:35])([F:37])[F:36])=[N:32][N:33]=4)[N:30]=3)[CH2:12][CH2:13]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazineHCID 38329951-[phenyl-[4-(trifluoromethyl)phenyl]methyl]piperazine

Product 1

HCID 86638060HCID 86638060, compound

Procedure

A mixture of 1-[phenyl-[4-(trifluoromethyl)phenyl]methyl]piperazine and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 3. The crude product was purified by hplc using a Waters XTerra C18 column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give 6-[4-[phenyl-[4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.

Workup

  1. customto react by General Synthetic Method 3
  2. customThe crude product was purified by hplc
  3. washeluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents

Sources & evidence

ORD record
ord-4cd17edd18074fab82a083700cfafc79
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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