6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → HCID 67340764, compound

Participants

Reaction Steps

A mixture of N-[[(9aR)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,6-a]pyrazin-7-yl]methyl]-2-methylquinolin-4-amine and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 3. The crude product was purified by hplc using a Waters XTerra C18 column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give N-[[(9aR)-2-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-1,3,4,6,7,8,9,9a-octahydropyrido[1,6-a]pyrazin-7-yl]methyl]-2-methylquinolin-4-amine.

Provenance & Evidence