HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → HCID 67340214, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine | HCID 613657 | — |
| Reactant | 1-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochloride | HCID 22709766 | — |
| Product | HCID 67340214 | HCID 67340214 | — |
Reaction Steps
A mixture of 1-(6-chloronaphthalen-2-yl)sulfonylpiperazine hydrochloride and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 4. The crude product was purified by hplc using a Waters XTerra C18 column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give 6-[4-(6-chloronaphthalen-2-yl)sulfonylpiperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003649B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-77317275b02a401e8571499e08bb138c |
| Source note | uspto-grants-2011_08 |