HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexanecarboxaldehyde → 6-[4-(Cyclohexylmethyl)piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexanecarboxaldehyde | HCID 16275 | — |
| Reactant | 6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine | HCID 1476862 | — |
| Product | 6-[4-(Cyclohexylmethyl)piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 67340606 | — |
Reaction Steps
Reductive amination of 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine with cyclohexanecarbaldehyde was carried out according to General Synthetic Method 6. The crude product was purified by hplc using a Waters XBridge Prep C18 OBD column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 1% aqueous ammonia) and acetonitrile as eluents to give 6-[4-(cyclohexylmethyl)piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003649B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-91c996b4b6f14243ac01c6fd9e3f503a |
| Source note | uspto-grants-2011_08 |