6-(Trifluoromethyl)pyridine-3-carboxaldehyde → 3-(Trifluoromethyl)-6-[4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]piperazin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine

Participants

Reaction Steps

Reductive amination of 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine with 6-(trifluoromethyl)pyridine-3-carbaldehyde was carried out according to General Synthetic Method 9. The crude product was purified by hplc using a Waters XBridge Prep C18 OBD column, 5μ silica, 30 mm diameter, 100 mm length eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give 3-(trifluoromethyl)-6-[4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]piperazin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine.

Provenance & Evidence