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6-Chloro-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine → 3-(Difluoromethyl)-6-[4-[1-(4-fluorophenyl)-1-methylethyl]piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Chloro-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 1472385 | — |
| 反応物 | 1-[2-(4-Fluorophenyl)propan-2-yl]piperazine | HCID 67340063 | — |
| 生成物 | 3-(Difluoromethyl)-6-[4-[1-(4-fluorophenyl)-1-methylethyl]piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine | HCID 59149774 | 62% |
反応手順
A mixture of 1-[1-(4-fluorophenyl)-1-methyl-ethyl]piperazine (obtained as described in J. Med. Chem. 2007, 50, 3528) and 6-chloro-3-(difluoromethyl)-[1,2,4]-triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 269 to give 3-(difluoromethyl)-6-[4-[1-(4-fluorophenyl)-1-methylethyl]piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 62% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08003649B2 |
| 出典データセット | uspto-grants-2011_08 |
| ORD ID | ord-c152674489bc4e7f907c8a9367708fce |
| 出典メモ | uspto-grants-2011_08 |