3-Fluorobenzaldehyde → HCID 59149768, compound

HRID 1674990Notes

Reaction equation

HRID 1674990 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[NH:10]1[CH2:15][CH:14]=[C:13]([C:16]2[CH:17]=[CH:18][C:19]3[N:20]([C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][N:24]=3)[N:21]=2)[CH2:12][CH2:11]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][N:10]1[CH2:11][CH:12]=[C:13]([C:16]2[CH:17]=[CH:18][C:19]3[N:20]([C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][N:24]=3)[N:21]=2)[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 680093-FluorobenzaldehydeHCID 67340789HCID 67340789, compound

Product 1

HCID 59149768HCID 59149768, compoundYield 46%

Procedure

A mixture of 3-fluorobenzaldehyde and 6-(3,6-dihydro-2H-pyridin-4-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 5 to give 6-[1-(3-fluorobenzyl)-1,2,3,6-tetrahydropyridin-4-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine in 46% yield.

Workup

  1. customto react by General Synthetic Method 5

Sources & evidence

ORD record
ord-54647edd1cd14363aa9999b24fc08027
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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