6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → HCID 59149809, compound

HRID 1675021Notes

Reaction equation

HRID 1675021 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:3]=1.Cl[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][N:24]=2)[N:21]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2([OH:14])[CH2:13][CH2:12][N:11]([C:16]3[CH:17]=[CH:18][C:19]4[N:20]([C:22]([C:25]([F:26])([F:28])[F:27])=[N:23][N:24]=4)[N:21]=3)[CH2:10][CH2:9]2)[CH:3]=1

Participants

3

Reactant 2

HCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazineHCID 67341775HCID 67341775, compound

Product 1

HCID 59149809HCID 59149809, compoundYield 81%

Procedure

A mixture of 4-(4-methylpyridin-2-yl)piperidin-4-ol and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by the method of Example 306 to give 4-(4-methylpyridin-2-yl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol in 81% yield.

Workup

  1. customto react by the method of Example 306

Sources & evidence

ORD record
ord-1a05958d934a43e793bf02b4f7641df8
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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