6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → HCID 59149813, compound

HRID 1675026Notes

Reaction equation

HRID 1675026 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1([OH:12])[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.Cl[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([C:23]([F:26])([F:25])[F:24])=[N:21][N:22]=2)[N:19]=1>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1([OH:12])[CH2:7][CH2:8][N:9]([C:14]2[CH:15]=[CH:16][C:17]3[N:18]([C:20]([C:23]([F:24])([F:26])[F:25])=[N:21][N:22]=3)[N:19]=2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazineHCID 57420365HCID 57420365, compound

Product 1

HCID 59149813HCID 59149813, compoundYield 65%

Procedure

A mixture of 4-(1,3-thiazol-2-yl)piperidin-4-ol and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by the method of Example 306 to give 4-(1,3-thiazol-2-yl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol in 65% yield.

Workup

  1. customto react by the method of Example 306

Sources & evidence

ORD record
ord-b2bf249ef50a4ba3bb53c17ed53082ca
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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