2-Bromothiazole → 1,1-Dimethylethyl 4-hydroxy-4-(2-thiazolyl)-1-piperidinecarboxylate

HRID 1675027Notes

Reaction equation

HRID 1675027 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.Br[C:16]1[S:17][CH:18]=[CH:19][N:20]=1>>[OH:1][C:2]1([C:16]2[S:17][CH:18]=[CH:19][N:20]=2)[CH2:3][CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 764302-BromothiazoleHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 574237961,1-Dimethylethyl 4-hydroxy-4-(2-thiazolyl)-1-piperidinecarboxylateYield 80%

Procedure

Obtained in 80% yield by an analogous method to Example 323, preparation of starting materials, starting from tert-butyl 4-oxo-1-piperidinecarboxylate and 2-bromothiazole.

Workup

  1. customObtained in 80% yield by an analogous method to Example 323, preparation of starting materials

Sources & evidence

ORD record
ord-cd4090aaa61840db9a77fd94d7fc8459
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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