HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → ethyl (2E)-3-[4-([4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]methyl)phenyl]prop-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine | HCID 1476862 | — |
| Reactant | HCID 13170167 | HCID 13170167 | — |
| Product | ethyl (2E)-3-[4-([4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]methyl)phenyl]prop-2-enoate | HCID 67339456 | 59% |
Reaction Steps
A mixture of ethyl (E)-3-(4-formylphenyl)prop-2-enoate and 6-(piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 7 to give ethyl (2E)-3-[4-([4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]methyl)phenyl]prop-2-enoate in 59% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003649B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-287f5d7993da490488b325dd0f50ba51 |
| Source note | uspto-grants-2011_08 |