1-Phenethylpiperazine → 3-[Chloro(difluoro)methyl]-6-[4-(2-phenylethyl)piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine

HRID 1675036Notes

Reaction equation

HRID 1675036 reaction equation
[CH2:1]([N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([Cl:28])([F:27])[F:26])=[N:23][N:24]=2)[N:21]=1>>[Cl:28][C:25]([F:26])([F:27])[C:22]1[N:20]2[N:21]=[C:16]([N:12]3[CH2:11][CH2:10][N:9]([CH2:1][CH2:2][C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=4)[CH2:14][CH2:13]3)[CH:17]=[CH:18][C:19]2=[N:24][N:23]=1

Participants

3

Reactant 2

HCID 792141-PhenethylpiperazineHCID 14891146-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine

Product 1

HCID 591497493-[Chloro(difluoro)methyl]-6-[4-(2-phenylethyl)piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazineYield 71%

Procedure

A mixture of 1-phenethylpiperazine and 6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 339 to give 3-[chloro(difluoro)methyl]-6-[4-(2-phenylethyl)piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 71% yield.

Workup

  1. customto react by an analogous method to Example 339

Sources & evidence

ORD record
ord-4eb05b6fdc0b4db08412f5ed84ea7ff1
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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