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HRID1675038

反应详情

EQUATION

反应方程式

HRID 1675038 的结构方程式

REACTANTS

反应物

2
结构：FC(F)(F)c1cnc(N2CCCNCC2)c(Cl)c1
HCID735734

1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepane

C11H13ClF3N3

结构：FC(F)(Cl)c1nnc2ccc(Cl)nn12
HCID1489114

6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine

C6H2Cl2F2N4

PRODUCTS

生成物

1
结构：FC(F)(F)c1cnc(N2CCCN(c3ccc4nnc(C(F)(F)Cl)n4n3)CC2)c(Cl)c1
HCID59149718

未命名化合物

收率 62%

PROCEDURE

实验过程

A mixture of 1-(3-chloro-5-trifluoromethyl-2-pyridyl)-1,4-diazepane and 6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 339 to give 3-[chloro(difluoro)methyl]-6-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 62% yield.

WORKUP

后处理

  1. customto react by an analogous method to Example 339