6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → HCID 59149837, compound

HRID 1675048Notes

Reaction equation

HRID 1675048 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7](Cl)(=[O:9])=[O:8].[N:11]1([C:17]2[CH:18]=[CH:19][C:20]3[N:21]([C:23]([C:26]([F:29])([F:28])[F:27])=[N:24][N:25]=3)[N:22]=2)[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([N:14]1[CH2:13][CH2:12][N:11]([C:17]2[CH:18]=[CH:19][C:20]3[N:21]([C:23]([C:26]([F:27])([F:28])[F:29])=[N:24][N:25]=3)[N:22]=2)[CH2:16][CH2:15]1)(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 14768626-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 3787675Pyridine-2-sulfonyl Chloride

Product 1

HCID 59149837HCID 59149837, compoundYield 32%

Procedure

Obtained in 32% yield by an analogous method to Example 394, starting from pyridine-2-sulfonyl chloride and 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.

Workup

  1. customObtained in 32% yield by an analogous method to Example 394

Sources & evidence

ORD record
ord-b3f3e2034c594f1396f3b578986028a9
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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