Benzyl 3-hydroxyphenyl ether → HCID 67341469, compound

HRID 1675058Notes

Reaction equation

HRID 1675058 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:16][C:17]([F:35])([F:34])[C:18]1[N:22]2[N:23]=[C:24]([N:27]3[CH2:32][CH2:31][CH:30](O)[CH2:29][CH2:28]3)[CH:25]=[CH:26][C:21]2=[N:20][N:19]=1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][CH:14]=1)[O:15][CH:30]1[CH2:31][CH2:32][N:27]([C:24]2[CH:25]=[CH:26][C:21]3[N:22]([C:18]([C:17]([F:34])([F:35])[F:16])=[N:19][N:20]=3)[N:23]=2)[CH2:28][CH2:29]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 138048Benzyl 3-hydroxyphenyl etherHCID 245876321-[3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

Product 1

HCID 67341469HCID 67341469, compoundYield 40%

Procedure

Obtained in 40% yield by an analogous procedure to Example 430, preparation of starting materials, starting from 3-(benzyloxy)phenol and 1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol.

Workup

  1. customObtained in 40% yield by an analogous procedure to Example 430, preparation of starting materials

Sources & evidence

ORD record
ord-441b57b98753450bb1bc9fd23b6d9585
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

Loading…