4-Chloro-2-pyridinecarbonitrile → 4-[[1-[3-(Trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]oxy]pyridine-2-carbonitrile

HRID 1675061Notes

Reaction equation

HRID 1675061 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[CH:3]=1.[F:10][C:11]([F:29])([F:28])[C:12]1[N:16]2[N:17]=[C:18]([N:21]3[CH2:26][CH2:25][CH:24]([OH:27])[CH2:23][CH2:22]3)[CH:19]=[CH:20][C:15]2=[N:14][N:13]=1>>[F:29][C:11]([F:10])([F:28])[C:12]1[N:16]2[N:17]=[C:18]([N:21]3[CH2:26][CH2:25][CH:24]([O:27][C:2]4[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[CH:3]=4)[CH2:23][CH2:22]3)[CH:19]=[CH:20][C:15]2=[N:14][N:13]=1

Participants

3

Reactant 2

HCID 6933424-Chloro-2-pyridinecarbonitrileHCID 245876321-[3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

Product 1

HCID 591498054-[[1-[3-(Trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]oxy]pyridine-2-carbonitrileYield 62%

Procedure

Obtained in 62% yield by an analogous procedure to Example 448, starting from 4-chloro-2-cyanopyridine and 1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol.

Workup

  1. customObtained in 62% yield by an analogous procedure to Example 448

Sources & evidence

ORD record
ord-cc4249db321c4f059f3dc051383d3483
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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