6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → HCID 67340242, compound

HRID 1675062Notes

Reaction equation

HRID 1675062 reaction equation
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([C:16]([F:19])([F:18])[F:17])=[N:14][N:15]=3)[N:12]=2)[CH2:6][CH2:5]N[CH2:3][CH2:2]1.[NH:20]1[C:24]2=[CH:25][N:26]=[CH:27][CH:28]=[C:23]2[C:22]([CH:29]=O)=[CH:21]1>>[NH:20]1[C:24]2=[CH:25][N:26]=[CH:27][CH:28]=[C:23]2[C:22]([CH:29]2[CH2:3][CH2:2][N:1]([C:7]3[CH:8]=[CH:9][C:10]4[N:11]([C:13]([C:16]([F:17])([F:18])[F:19])=[N:14][N:15]=4)[N:12]=3)[CH2:6][CH2:5]2)=[CH:21]1

Participants

3

Reactant 2

HCID 14768626-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 263379881H-Pyrrolo[2,3-c]pyridine-3-carbaldehyde

Product 1

HCID 67340242HCID 67340242, compoundYield 68%

Procedure

Obtained in 68% yield by General Synthetic Method 5, starting from 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine and 1H-pyrrolo[2,3-c]pyridine-3-carboxaldehyde (obtained as described in J. Chem. Soc. (C) 1970, 498).

Workup

  1. customObtained in 68% yield by General Synthetic Method 5

Sources & evidence

ORD record
ord-f2997c36bb7b4e97824d12454c1f7102
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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