Fumaric Acid → 6-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine fumarate

HRID 1675108Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1675108
[CH3:1][N:2]1[C:6]([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][N:19]([C:22]4[CH:23]=[CH:24][C:25]5[N:26]([C:28]([C:31]([F:34])([F:33])[F:32])=[N:29][N:30]=5)[N:27]=4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)=[CH:5][CH:4]=[N:3]1.[C:35]([OH:42])(=[O:41])/[CH:36]=[CH:37]/[C:38]([OH:40])=[O:39]>CC(C)=O>[C:35]([OH:42])(=[O:41])/[CH:36]=[CH:37]/[C:38]([OH:40])=[O:39].[CH3:1][N:2]1[C:6]([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[CH:12][C:13]([N:16]3[CH2:17][CH2:18][N:19]([C:22]4[CH:23]=[CH:24][C:25]5[N:26]([C:28]([C:31]([F:32])([F:33])[F:34])=[N:29][N:30]=5)[N:27]=4)[CH2:20][CH2:21]3)=[CH:14][CH:15]=2)=[CH:5][CH:4]=[N:3]1

Komponenten

4

Edukt 2

HCID 444972Fumaric AcidHCID 441259726-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

Produkt 1

HCID 673409226-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine fumarate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

3 ml of acetone was added to 50 mg of 6-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine and heated to form a solution. 12.3 mg of fumaric acid was dissolved in 3 ml of acetone. The compound solution was added to the counter-ion solution and the resultant mixture shaken with heat. The solution was dried under air and once the volume had dramatically reduced, solid 6-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine fumarate precipitated out.

Aufarbeitung

  1. temperatureheated
  2. customto form a solution
  3. additionThe compound solution was added to the counter-ion solution
  4. temperaturewith heat
  5. customThe solution was dried under air and once the volume
  6. customsolid 6-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine fumarate precipitated out

Quellen und Nachweise

ORD-Eintrag
ord-08df8d9a70c64afb83fbf25df15f733b
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08003649B2

Notizen zur Reaktion

Wird geladen…