反应详情

3 ml of acetone was added to 50 mg of 6-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine and heated to form a solution. 12.3 mg of fumaric acid was dissolved in 3 ml of acetone. The compound solution was added to the counter-ion solution and the resultant mixture shaken with heat. The solution was dried under air and once the volume had dramatically reduced, solid 6-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine fumarate precipitated out.

1. temperatureheated
2. customto form a solution
3. additionThe compound solution was added to the counter-ion solution
4. temperaturewith heat
5. customThe solution was dried under air and once the volume
6. customsolid 6-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine fumarate precipitated out