HCID 59149778, compound → HCID 59149736, compound

HRID 1675114Notes

Reaction equation

HRID 1675114 reaction equation
O1CC[CH:4]([O:7][CH2:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:16]=[CH:17][C:18]4[N:19]([C:21]([C:24]([F:27])([F:26])[F:25])=[N:22][N:23]=4)[N:20]=3)[CH2:11][CH2:10]2)[CH2:3][CH2:2]1.[Cl:28][C:29]1[N:34]=C(O)C=C[CH:30]=1>>[Cl:28][C:29]1[N:34]=[C:4]([O:7][CH2:8][CH:9]2[CH2:10][CH2:11][N:12]([C:15]3[CH:16]=[CH:17][C:18]4[N:19]([C:21]([C:24]([F:27])([F:25])[F:26])=[N:22][N:23]=4)[N:20]=3)[CH2:13][CH2:14]2)[CH:3]=[CH:2][CH:30]=1

Participants

3

Reactant 2

HCID 59149778HCID 59149778, compoundHCID 1785160256-chloropyridin-2-ol

Product 1

HCID 59149736HCID 59149736, compoundYield 75%

Procedure

Obtained in 75% yield by an analogous method to Example 447, starting from [1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]methanol (obtained as described in Example 294, preparation of starting materials) and 6-chloropyridin-2-ol.

Workup

  1. customObtained in 75% yield by an analogous method to Example 447

Sources & evidence

ORD record
ord-492140cbafda47f98b455bac43637a6c
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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