4-Bromopyridinium chloride → Ethyl 3-(pyridin-4-yl)benzoate

HRID 1675127Notes

Reaction equation

HRID 1675127 reaction equation
Cl.Br[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1.[CH2:9]([O:11][C:12]([C:14]1[CH:15]=[C:16](B(O)O)[CH:17]=[CH:18][CH:19]=1)=[O:13])[CH3:10]>>[N:6]1[CH:7]=[CH:8][C:3]([C:18]2[CH:19]=[C:14]([CH:15]=[CH:16][CH:17]=2)[C:12]([O:11][CH2:9][CH3:10])=[O:13])=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 881004-Bromopyridinium chlorideHCID 3249312(3-Ethoxycarbonylphenyl)boronic acid

Product 1

HCID 11356603Ethyl 3-(pyridin-4-yl)benzoateYield 92%

Procedure

Obtained in 92% yield by an analogous procedure to Example 605, starting from 4-bromopyridine hydrochloride and 3-(ethoxycarbonyl)phenylboronic acid.

Workup

  1. customObtained in 92% yield by an analogous procedure to Example 605

Sources & evidence

ORD record
ord-19facac793ad448887497e41ba003014
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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