(3-hydroxyphenyl)boronic Acid → HCID 67339657, compound

HRID 1675132Notes

Reaction equation

HRID 1675132 reaction equation
FC(F)(F)S(O[C:7]1[CH2:8][CH2:9][N:10]([C:13]2[CH:14]=[CH:15][C:16]3[N:17]([C:19]([C:22]([F:25])([F:24])[F:23])=[N:20][N:21]=3)[N:18]=2)[CH2:11][CH:12]=1)(=O)=O.[OH:28][C:29]1[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][CH:34]=1>>[F:23][C:22]([F:25])([F:24])[C:19]1[N:17]2[N:18]=[C:13]([N:10]3[CH2:11][CH:12]=[C:7]([C:33]4[CH:34]=[C:29]([OH:28])[CH:30]=[CH:31][CH:32]=4)[CH2:8][CH2:9]3)[CH:14]=[CH:15][C:16]2=[N:21][N:20]=1

Participants

3

Reactant 2

HCID 2734359(3-hydroxyphenyl)boronic AcidHCID 59578372HCID 59578372, compound

Product 1

HCID 67339657HCID 67339657, compoundYield 72%

Procedure

Obtained in 72% yield by an analogous procedure to Example 605, starting from 1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate and 3-hydroxyphenylboronic acid.

Workup

  1. customObtained in 72% yield by an analogous procedure to Example 605

Sources & evidence

ORD record
ord-065d94607cda4755be9ca37ed242dffc
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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