HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-[4-[2-(Difluoromethyl)-5-fluorobenzyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → 3-(Difluoromethyl)-6-[4-[2-(difluoromethyl)-5-fluorobenzyl]piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-[4-[2-(Difluoromethyl)-5-fluorobenzyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine | HCID 44125926 | — |
| Reactant | 3-(Difluoromethyl)-6-(piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 67341881 | — |
| Product | 3-(Difluoromethyl)-6-[4-[2-(difluoromethyl)-5-fluorobenzyl]piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine | HCID 67339373 | 58% |
Reaction Steps
Obtained in 58% yield by General Synthetic Method 5, starting from 3-(difluoromethyl)-6-(piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine (obtained as described in Examples 248-263, preparation of starting materials) and 2-difluoromethyl-5-fluorobenzaldehyde (obtained as described in Example 779, preparation of starting materials).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003649B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-64b825fdb0a249f59b4fddffbf1f765d |
| Source note | uspto-grants-2011_08 |