6-[4-[2-(Difluoromethyl)-5-fluorobenzyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → 6-[4-[2-(Difluoromethyl)-5-fluorobenzyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine

HRID 1675145Notes

Reaction equation

HRID 1675145 reaction equation
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([C:16]([F:19])([F:18])[F:17])=[N:14][N:15]=3)[CH:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:20][CH:21]([F:49])[C:22]1[CH:47]=[CH:46][C:45]([F:48])=[CH:44][C:23]=1[CH2:24]N1CCN(C2C=CC3N(C(C(F)(F)F)=NN=3)N=2)CC1>>[F:49][CH:21]([F:20])[C:22]1[CH:47]=[CH:46][C:45]([F:48])=[CH:44][C:23]=1[CH2:24][N:4]1[CH2:3][CH2:2][N:1]([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([C:16]([F:18])([F:17])[F:19])=[N:14][N:15]=3)[CH:12]=2)[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 441259266-[4-[2-(Difluoromethyl)-5-fluorobenzyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 673412226-(Piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

Product 1

HCID 591497866-[4-[2-(Difluoromethyl)-5-fluorobenzyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridineYield 39%

Procedure

Obtained in 39% yield by General Synthetic Method 9, starting from 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine and 2-difluoromethyl-5-fluorobenzaldehyde (obtained as described in Example 779, preparation of starting materials).

Workup

  1. customObtained in 39% yield by General Synthetic Method 9

Sources & evidence

ORD record
ord-cdbd7a9cc14e40f886d0066c6454fdf2
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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