6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → HCID 59149687, compound

HRID 1675147Notes

Reaction equation

HRID 1675147 reaction equation
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([C:16]([F:19])([F:18])[F:17])=[N:14][N:15]=3)[N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.FC(F)C1N2N=C(N3CCN([CH2:37][C:38]4[CH:43]=[CH:42][C:41]([CH:44]([F:46])[F:45])=[CH:40][CH:39]=4)CC3)C=CC2=NN=1>>[F:45][CH:44]([F:46])[C:41]1[CH:42]=[CH:43][C:38]([CH2:37][N:4]2[CH2:3][CH2:2][N:1]([C:7]3[CH:8]=[CH:9][C:10]4[N:11]([C:13]([C:16]([F:17])([F:18])[F:19])=[N:14][N:15]=4)[N:12]=3)[CH2:6][CH2:5]2)=[CH:39][CH:40]=1

Participants

3

Reactant 2

HCID 14768626-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 59149757HCID 59149757, compound

Product 1

HCID 59149687HCID 59149687, compoundYield 23%

Procedure

Obtained in 23% yield by General Synthetic Method 5, starting from 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine and 4-difluoromethylbenzaldehyde (obtained as described in Example 826, preparation of starting materials).

Workup

  1. customObtained in 23% yield by General Synthetic Method 5

Sources & evidence

ORD record
ord-7c6e69f8dedf4aa6a3c717736e61dc9f
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

Loading…