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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675149Generated: October 30, 2026

N-(2-Hydroxyethyl)imidazole → 6-[4-[4-[2-(1H-imidazol-1-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

https://huagongshe.com/reaction/1675149

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-Hydroxyethyl)imidazoleHCID 74168—
Reactant4-[4-[3-(Trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]phenolHCID 30008837—
Product6-[4-[4-[2-(1H-imidazol-1-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 591497826%

Reaction Steps

Obtained in 6% yield by an analogous method to Example 514, starting from 4-[4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]phenol and 1-(2-hydroxyethyl)imidazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003649B2
Source datasetuspto-grants-2011_08
ORD IDord-08600f4b153845e2bde88bffff8dd899
Source noteuspto-grants-2011_08