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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675152Generated: October 25, 2026

1H-Pyrazole-4-carbonitrile → 1-[2-[4-[4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]phenoxy]ethyl]-1H-pyrazole-4-carbonitrile

https://huagongshe.com/reaction/1675152

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-Pyrazole-4-carbonitrileHCID 564449—
Reactant6-[4-[4-(2-Bromoethoxy)phenyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazineHCID 67340326—
Product1-[2-[4-[4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]phenoxy]ethyl]-1H-pyrazole-4-carbonitrileHCID 5914978075%

Reaction Steps

Obtained in 75% yield by an analogous method to Example 847, starting from 6-[4-[4-(2-bromoethoxy)phenyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine and 4-cyanopyrazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003649B2
Source datasetuspto-grants-2011_08
ORD IDord-0c3eecf337c24b3882eddb9bc66e6b2d
Source noteuspto-grants-2011_08