4-Cyanobenzenesulfonyl chloride → HCID 37926284, compound

HRID 1675160Notes

Reaction equation

HRID 1675160 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].[N:13]1([C:19]2[CH:20]=[CH:21][C:22]3[N:23]([C:25]([C:28]([F:31])([F:30])[F:29])=[N:26][N:27]=3)[N:24]=2)[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[F:31][C:28]([F:29])([F:30])[C:25]1[N:23]2[C:22]([CH:21]=[CH:20][C:19]([N:13]3[CH2:18][CH2:17][N:16]([S:9]([C:6]4[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=4)(=[O:11])=[O:10])[CH2:15][CH2:14]3)=[N:24]2)=[N:27][N:26]=1

Participants

3

Reactant 2

HCID 394974-Cyanobenzenesulfonyl chlorideHCID 14768626-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

Product 1

HCID 37926284HCID 37926284, compoundYield 32%

Procedure

Obtained in 32% yield by an analogous procedure to Example 394, starting from 4-cyanobenzenesulfonyl chloride and 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.

Workup

  1. customObtained in 32% yield by an analogous procedure to Example 394

Sources & evidence

ORD record
ord-d44672afc6214161aec0033b3670e533
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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