6-Chloro-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine → HCID 59149790, compound

HRID 1675161Notes

Reaction equation

HRID 1675161 reaction equation
ClC1C=CC2N(C(C(F)F)=NN=2)N=1.[F:14][C:15]1[CH:16]=[C:17]([CH:38]=[C:39]([S:41]([CH3:44])(=[O:43])=[O:42])[CH:40]=1)[CH2:18][N:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:26]=[CH:27][C:28]3[N:29]([C:31]([C:34](F)([F:36])[F:35])=[N:32][N:33]=3)[N:30]=2)[CH2:21][CH2:20]1>>[F:36][CH:34]([F:35])[C:31]1[N:29]2[N:30]=[C:25]([N:22]3[CH2:23][CH2:24][N:19]([CH2:18][C:17]4[CH:38]=[C:39]([S:41]([CH3:44])(=[O:42])=[O:43])[CH:40]=[C:15]([F:14])[CH:16]=4)[CH2:20][CH2:21]3)[CH:26]=[CH:27][C:28]2=[N:33][N:32]=1

Participants

3

Reactant 2

HCID 14723856-Chloro-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazineHCID 59149785HCID 59149785, compound

Product 1

HCID 59149790HCID 59149790, compoundYield 55%

Procedure

Obtained in 55% yield by General Synthetic Method 5, starting from 6-chloro-3-difluoromethyl-[1,2,4]triazolo[4,3-b]pyridazine and 3-fluoro-5-methylsulfonylbenzaldehyde (obtained as described in Example 778, preparation of starting materials).

Workup

  1. customObtained in 55% yield by General Synthetic Method 5

Sources & evidence

ORD record
ord-29cb4a7b688c418aa299fb4ec9534bf1
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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