Allitinib metabolite M6 → HCID 67335614, compound

HRID 1675200Notes

Reaction equation

HRID 1675200 reaction equation
CO[C:3](=O)[CH2:4][CH2:5][C@H:6]([NH2:37])[C:7](=[O:36])[NH:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]=[CH:14][N:13]=[C:12]2[NH:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=2)=[C:22]([Cl:35])[CH:21]=1.ClC1C=C(NC2C3C(=CC=C(N)C=3)N=CN=2)C=CC=1OCC1C=CC=C(F)C=1>>[Cl:35][C:22]1[CH:21]=[C:20]([NH:19][C:12]2[C:11]3[C:16](=[CH:17][CH:18]=[C:9]([NH:8][C:7]([CH:6]4[CH2:5][CH2:4][CH2:3][NH:37]4)=[O:36])[CH:10]=3)[N:15]=[CH:14][N:13]=2)[CH:25]=[CH:24][C:23]=1[O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=1

Participants

3

Reactant 2

HCID 53630477Allitinib metabolite M6HCID 86617504HCID 86617504, compound

Product 1

HCID 67335614HCID 67335614, compoundYield 82%

Procedure

The procedure of (13-1) of Example 13 was repeated except for using 448 mg of the compound obtained in Example 15 instead of the compound obtained in Example 12 to obtain the title compound (297 mg, 82%).

Sources & evidence

ORD record
ord-5bbe020ed5804a1299e61d374e966283
Source dataset
uspto-grants-2011_08
Patent number
US08003658B2

Reaction notes

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