HRID1675200

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：Nc1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

HCID53630477

4-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazoline-4,6-diamine

C21H16ClFN4O

反应SMILES：COC(=O)CC[C@H](N)C(=O)Nc1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

HCID86617504

未命名化合物

PRODUCTS

产物

反应SMILES：O=C(Nc1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1)C1CCCN1

HCID67335614

未命名化合物

收率 82%

PROCEDURE

实验过程

The procedure of (13-1) of Example 13 was repeated except for using 448 mg of the compound obtained in Example 15 instead of the compound obtained in Example 12 to obtain the title compound (297 mg, 82%).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-5bbe020ed5804a1299e61d374e966283
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08003658B2
来源说明: uspto-grants-2011_08

反应SMILES

CO[C:3](=O)[CH2:4][CH2:5][C@H:6]([NH2:37])[C:7](=[O:36])[NH:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]=[CH:14][N:13]=[C:12]2[NH:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=2)=[C:22]([Cl:35])[CH:21]=1.ClC1C=C(NC2C3C(=CC=C(N)C=3)N=CN=2)C=CC=1OCC1C=CC=C(F)C=1>>[Cl:35][C:22]1[CH:21]=[C:20]([NH:19][C:12]2[C:11]3[C:16](=[CH:17][CH:18]=[C:9]([NH:8][C:7]([CH:6]4[CH2:5][CH2:4][CH2:3][NH:37]4)=[O:36])[CH:10]=3)[N:15]=[CH:14][N:13]=2)[CH:25]=[CH:24][C:23]=1[O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=1