HuagongsheHuagongshe Chemistry Print Report · For research reference only
Monoethyl oxalate → 3-Amino-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Monoethyl oxalate | HCID 74701 | — |
| Reactant | N-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-3-(2-methoxy-acetylamino)-propionamide | HCID 11562882 | — |
| Product | 3-Amino-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)propanamide | HCID 67334123 | — |
Reaction Steps
The procedure of (20-2) of Example 20 was repeated except for using oxalic acid monoethylester and 0.09 g of the compound obtained in (20-1) of Example 20 instead of methoxyacetic acid, and subjecting column chromatography (eluent-chloroform:methanol=15:1) to obtain the title compound (0.04 g, 37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003658B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-0a2ac6a4a9084a5ca1af7f0982af2f9e |
| Source note | uspto-grants-2011_08 |