Cyclopropanecarboxylic acid → 3-Amino-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)propanamide

Participants

Role	Name	HCID	Charge
Reactant	Cyclopropanecarboxylic acid	HCID 15655	—
Reactant	N-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-3-(2-methoxy-acetylamino)-propionamide	HCID 11562882	—
Product	3-Amino-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)propanamide	HCID 67334123	—

Reaction Steps

The procedure of (20-2) of Example 20 was repeated except for using cyclopropylcarboxylic acid and 0.09 g of the compound obtained in (20-1) of Example 20 instead of methoxyacetic acid, and subjecting column chromatography (eluent-chloroform:methanol=15:1) to obtain the title compound (0.05 g, 49%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08003658B2
Source dataset	uspto-grants-2011_08
ORD ID	ord-e0aae858eb3a4f6c8da5007aee368f7d
Source note	uspto-grants-2011_08