3-Methyl-4-((6-methylpyridin-3-yl)oxy)aniline → HCID 69222141, compound

HRID 1675205Notes

Reaction equation

HRID 1675205 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][NH:8][C:7]2=O)([O-])=O.ClC1C=C(NC2C3C(=CC=C(N)C=3)N=CN=2)C=CC=1OCC1C=CC=C(F)C=1.[CH3:43][C:44]1[CH:45]=[C:46]([NH2:58])[CH:47]=[CH:48][C:49]=1[O:50][C:51]1[CH:52]=[N:53][C:54]([CH3:57])=[CH:55][CH:56]=1>>[CH3:43][C:44]1[CH:45]=[C:46]([NH:58][C:7]2[C:6]3[C:11](=[CH:12][CH:13]=[C:4]([NH2:1])[CH:5]=3)[N:10]=[CH:9][N:8]=2)[CH:47]=[CH:48][C:49]=1[O:50][C:51]1[CH:52]=[N:53][C:54]([CH3:57])=[CH:55][CH:56]=1

Participants

4

Reactant 3

HCID 114244343-Methyl-4-((6-methylpyridin-3-yl)oxy)anilineHCID 53630477Allitinib metabolite M6HCID 1353985026-Nitro-3,4-dihydroquinazolin-4-one

Product 1

HCID 69222141HCID 69222141, compoundYield 56%

Procedure

The procedures of (1-1) to (1-4) of Example 1 were repeated except for using 3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamine instead of 3-chloro-4-(3-fluoro-benzyloxy)-phenylamine to obtain the title compound (0.38 g, 56%).

Sources & evidence

ORD record
ord-72d4528a5ae84c26af5202f842c99ddd
Source dataset
uspto-grants-2011_08
Patent number
US08003658B2

Reaction notes

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