4-Amino-N-phenylbenzamide → HCID 11562741, compound

Participants

Reaction Steps

1 g of 2-[3-cyano-4-(dimethylamino-methylene amino)-phenylcarbamoyl]-ethyl-carbamic acid t-butylester (see, Journal of Medicinal Chemistry 2004, 44:2719) dissolved in 6 ml of acetic acid was reacted with 650 mg of 4-amino-N-phenyl-benzamide at 60° C. for 3 hours, and the resulting residue was stirred in 100 ml of saturated aqueous sodium bicarbonate solution at room temperature for 30 mins. The reacted solution was extracted with 30 ml of ethylacetate 3 times, dried over anhydrous magnesium sulfate, filtered and distilled under a reduced pressure, and the resulting residue was subjected to column chromatography (eluent-chloroform:methanol=15:1) to obtain the title compound (350 mg, 25%).

Provenance & Evidence