HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)propanamide → 5-Amino-pentanoic acid {4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)propanamide | HCID 67334123 | — |
| Reactant | (4-{4-[3-Chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-ylcarbamoyl}-butyl)-carbamic acid t-butylester | HCID 86617510 | — |
| Product | 5-Amino-pentanoic acid {4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-amide | HCID 67334133 | 98% |
Reaction Steps
The procedure of (20-1) of Example 20 was repeated except for using 0.42 g of the compound obtained in Example 114 instead of the compound obtained in Example 19 to obtain the title compound (0.34 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003658B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-6084e81d84514cc3afb4d71007d2b1be |
| Source note | uspto-grants-2011_08 |