HCID 67334152, compound → HCID 67334757, compound

HRID 1675227Notes

Reaction equation

HRID 1675227 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([N:28]([CH3:38])[C:29]([CH2:31][CH2:32][NH:33]C(=O)C=C)=[O:30])[CH:26]=3)[N:21]=[CH:20][N:19]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1.NCCC(N(C1C=C2C(=CC=1)N=CN=C2NC1C=CC(OCC2C=CC=C(F)C=2)=C(Cl)C=1)CC)=O>>[NH2:33][CH2:32][CH2:31][C:29]([N:28]([C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[N:21]=[CH:20][N:19]=[C:18]2[NH:17][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=2)=[C:2]([Cl:1])[CH:3]=1)[CH3:38])=[O:30]

Participants

3

Reactant 2

HCID 67334152HCID 67334152, compoundHCID 67335206HCID 67335206, compound

Product 1

HCID 67334757HCID 67334757, compound

Procedure

The procedure of (139-5) of Example 139 was repeated except for using 3-amino-N-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-N-ethyl-propionamide instead of the compound obtained in (139-4) of Example 139 to obtain the title compound (15 mg, 5%).

Sources & evidence

ORD record
ord-3beebaca7d754383976a44114a84d5b3
Source dataset
uspto-grants-2011_08
Patent number
US08003658B2

Reaction notes

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