HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- → 6-Amino-4-[3-chloro-4-(2-pyridylmethoxy)anilino]quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Reactant | ({4-[3-Chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-ylcarbamoyl}-methyl)-carbamic acid t-butylester | HCID 11570293 | — |
| Product | 6-Amino-4-[3-chloro-4-(2-pyridylmethoxy)anilino]quinazoline | HCID 18967687 | — |
Reaction Steps
The procedure of (1-5) of Example 1 was repeated except for using 414 mg of (2S)-pyrrolidine-1,2-dicarboxylic acid-1-t-butylester instead of 2-t-butoxycarbonylamino-ethanoic acid and 368 mg of the compound obtained in (145-2) to obtain the title compound (200 mg, 35%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003658B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-7c521ce2b07d4ad3841086e94ee29950 |
| Source note | uspto-grants-2011_08 |