Acrylic Acid → HCID 67334224, compound

Participants

Reaction Conditions

Reaction Steps

480 mg of (2S)-2-amino-4-methyl-pentanoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide was dissolved in 10 ml of THF, cooled to 0° C., and the resulting solution was treated with 0.1 ml of acrylic acid, 0.16 ml of pyridine and 376 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride at 0° C. for 1 hour and at room temperature for 2 hours. The resulting solution was treated with saturated sodium bicarbonate, extracted with chloroform, dried over anhydrous sodium sulfate, filtered and distilled under a reduced pressure. The resulting residue was subjected to column chromatography (eluent-ethylacetate:methanol=30:1) to obtain the title compound of formula (162 mg, 31%).

Provenance & Evidence