HCID 24898113, compound → HCID 24898772, compound

HRID 1675280Notes

Reaction equation

[CH2:1]=[C:2]([C:4]1[CH:27]=[CH:26][C:7]([CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([C@@H:16]([C:21]3[CH:25]=[CH:24][O:23][N:22]=3)[CH2:17][C:18]([OH:20])=[O:19])=[CH:12][CH:11]=2)=[CH:6][C:5]=1[O:28][C:29]([F:32])([F:31])[F:30])[CH3:3].C1(C2C=C(C=CC=2OC(F)(F)F)COC2C=CC([C@@H](C3C=CON=3)CC(O)=O)=CC=2)CCCC1>>[CH:2]([C:4]1[CH:27]=[CH:26][C:7]([CH2:8][O:9][C:10]2[CH:11]=[CH:12][C:13]([C@@H:16]([C:21]3[CH:25]=[CH:24][O:23][N:22]=3)[CH2:17][C:18]([OH:20])=[O:19])=[CH:14][CH:15]=2)=[CH:6][C:5]=1[O:28][C:29]([F:32])([F:31])[F:30])([CH3:3])[CH3:1]

Participants

Reactant 2

HCID 24898113HCID 24898113, compound

HCID 24898770HCID 24898770, compound

Product 1

HCID 24898772HCID 24898772, compound

Procedure

Compound 37 was synthesized from compound 35 using the procedure described above for the preparation of 23. 1H NMR (CD3CN) δ 1.25 (d, J=6.9 Hz, 6H), 2.96 (dd, J=7.4, 16.4 Hz, 1 H), 3.20 (dd, J=7.4, 16.4 Hz, 1 H), 3.34 (m, 1 H), 4.56 (m, 1 H), 5.09 (s, 2 H), 6.27 (d, J=1.7 Hz, 1H), 6.97 (d, J=6.6 Hz, 2 H), 7.25 (d, J=6.6 Hz, 2H), 7.37 (s, 1 H), 7.42 (d, J=8.1 Hz, 1H), 7.48 (d, J=8.1 Hz, 1 H), 8.45 (d, J=1.7 Hz, 1H). MS ESI (pos.) m/e: 450 (M+H).

Sources & evidence

ORD record: ord-4c55f6b27ac5494cb6db76bb203d8170
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08003648B2

Reaction notes

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