Hydrochloric Acid → HCID 59300623, compound

Participants

Reaction Steps

A solution of 39.3 (25 mg) in THF/MeOH (1:1, 4 mL) was treated with 2N aqueous NaOH solution (0.2 mL) and stirred for 2 hours at room temperature. The reaction mixture was acidified with aqueous 3N HCl while cooled with ice-water, and extracted with EtOAc to obtain 39, which was chromatographed on a silica gel column, eluting with 5˜10% MeOH in DCM. MS ESI (neg.) m/e: 480.1 (M−H). 1HNMR (CDCl3) δ 7.13 (s, 1H), 7.04 (d, 2H, J=7.27Hz), 7.01-6.98 (m, 2H), 6.80 (s, 1H), 6.69 (d, 2H, J=Hz, J=8.62Hz), 6.46 (d, 2H, J=8.61Hz), 4.99 (s, 1H), 4.59 (s, 2H), 3.95 (t, 1H, J=7.60Hz), 2.80 (m, 1H), 2.46 (m, 1H), 1.82 (s, 3H).

Provenance & Evidence