Pyridine → HCID 59300614, compound

HRID 1675313Notes

Reaction equation

HRID 1675313 reaction equation
[C:1]([O:4][CH2:5][C:6]1[S:7][CH:8]=[CH:9][C:10]=1[CH3:11])(=[O:3])[CH3:2].N1C=CC=CC=1.[Br:18]Br>C(Cl)Cl>[C:1]([O:4][CH2:5][C:6]1[S:7][C:8]([Br:18])=[CH:9][C:10]=1[CH3:11])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24408BromineHCID 59300595(3-Methylthiophen-2-yl)methyl acetate

Product 1

HCID 59300614HCID 59300614, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

To a solution of 62.3 (0.61 g, 3.58 mmol) and pyridine (0.29 mL, 3.58 mmol) in DCM (24 mL) was added bromine (3.58 mL, 1.0 M solution in DCM) dropwise at 0° C. The mixture was stirred for 30 minutes at 0° C. and warmed to room temperature over 1 Hour. Upon completion, the reaction was diluted with DCM, washed with saturated Na2S2O3 and brine, dried (Na2SO4), and concentrated to afford 62.4. The crude product was used without further purification.

Workup

  1. temperaturewarmed to room temperature over 1 Hour
  2. washwashed with saturated Na2S2O3 and brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-8ea5de703b8240f6801bd8d7e0d3bf21
Source dataset
uspto-grants-2011_08
Patent number
US08003648B2

Reaction notes

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