HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(Chloromethyl)-3-methyl-5-[4-(trifluoromethyl)phenyl]thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | [3-Methyl-5-(4-trifluoromethylphenyl)thien-2-yl]methanol | HCID 21986444 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(Chloromethyl)-3-methyl-5-[4-(trifluoromethyl)phenyl]thiophene | HCID 15946281 | — |
Reaction Steps
To a solution of 62.6 (63 mg, 0.23 mmol) in DCM (2.3 mL) were added triethylamine (32 μL, 0.23 mmol) and thionyl chloride (25 μL, 0.35 mmol) at room temperature. The mixture was stirred overnight and concentrated to afford 62.7. The crude product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003648B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cfedaa58355d466b95abaef9c1ba0e3d |
| Source note | uspto-grants-2011_08 |