3-(Dimethylamino)propyl chloride hydrochloride → HCID 25103527, compound

HRID 1675326Notes

Reaction equation

HRID 1675326 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=1)(=[O:13])=[O:12])[CH:6]=[CH:5]2.Cl.[CH3:22][N:23]([CH3:28])[CH2:24][CH2:25][CH2:26]Cl>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH2:26][CH2:25][CH2:24][N:23]([CH3:28])[CH3:22])[CH:15]=1)(=[O:13])=[O:12])[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 943083-(Dimethylamino)propyl chloride hydrochlorideHCID 67233067HCID 67233067, compound

Product 1

HCID 25103527HCID 25103527, compound

Procedure

5-Fluoro-1-(3-hydroxybenzenesulfonyl) indole was treated in a similar procedure as given in the Example 1 with 3-dimethylaminopropylchloride hydrochloride (2.48 mmol, 0.393 grams), with some non-critical variations to obtain the above derivative.

Workup

  1. customto obtain the above derivative

Sources & evidence

ORD record
ord-537b15fb88c54524af97c97f27df6a48
Source dataset
uspto-grants-2011_08
Patent number
US08003670B2

Reaction notes

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