HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675328Generated: November 1, 2026
3,4-Dichloro-5-isothiazolecarboxylic acid → 3,4-Dichloro-5-isothiazolecarbonyl chloride
https://huagongshe.com/reaction/1675328
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3,4-Dichloro-5-isothiazolecarboxylic acid | HCID 49837 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3,4-Dichloro-5-isothiazolecarbonyl chloride | HCID 10976886 | — |
Reaction Steps
To 4.0 g (20.3 mmol) of 3,4-dichloroisothiazole-5-carboxylic acid were added 8 ml of oxalyl chloride and a catalytic amount of N,N-dimethylformamide (DMF). The mixture was stirred at 50° C. for 30 minutes. The reaction mixture was concentrated under vacuum to obtain 3,4-dichloroisothiazole-5-carbonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08003675B2 |
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| Source dataset | uspto-grants-2011_08 |
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| ORD ID | ord-f0f94cbc890e42798fb29712a0ce3996 |
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| Source note | uspto-grants-2011_08 |
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