HCID 59179737, compound → HCID 178472466, compound

Participants

Reaction Steps

Palladium (10 wt. %) on carbon (500 mg) was added in one portion to a solution of 4-(3-fluoro-4-nitro-phenoxy)-cyclohexanecarboxylic acid ethyl ester (2.6 g, 8.35 mmol) in ethanol (75 mL) and the mixture was stirred under a hydrogen atmosphere for 6 h. The reaction mixture was filtered and concentrated in vacuo to leave a residue. The residue was purified by column chromatography, using a gradient of 20-50% EtOAc and isohexane as eluent, to give the title compound as a pale yellow solid (2.0 g, 85%)

Provenance & Evidence