HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[2-(Acetylamino)ethyl]-6-methoxy-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 1-[2-(acetylamino)ethyl]-6-methoxy-1H-indole-2-carboxylate | HCID 67330577 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[2-(Acetylamino)ethyl]-6-methoxy-1H-indole-2-carboxylic acid | HCID 42604212 | — |
Reaction Steps
Dissolve 0.69 g of the compound obtained in Step B in 10 ml of absolute ethanol and add 2.5 ml of sodium hydroxide solution (1M) and reflux for 16 hours. Cool and add 20 ml of water and acidify the reaction mixture with hydrochloric acid (5M). Filter off the precipitate and wash it with water. The title product is obtained in the form of a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003682B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-0fc479a3fa0e41a88541f5c975f25e63 |
| Source note | uspto-grants-2011_08 |