Trifluoroacetic acid → HCID 25105788, compound

Participants

Reaction Steps

2-Trifluoromethylbenzoyl chloride (50.4 mg, 0.24 mmol) was added at RT to ethyl 2-(3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)thiazole-5-carboxylate; trifluoroacetic acid salt (60 mg, 0.16 mmol) and triethylamine (64 μl, 0.46 mmol) in 4 ml of methylene chloride and 2 ml of pyridine. After 3 h at RT, the mixture was concentrated, water and ethyl acetate were added, and the organic phase was removed, concentrated by evaporation and purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 63 mg (91%), M+H+: 438.04.

Provenance & Evidence