HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoamylamine → HCID 58459790, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoamylamine | HCID 7894 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58459773 | HCID 58459773 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58459790 | HCID 58459790 | — |
Reaction Steps
tert-Butyl 5-(5-carboxythiazol-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-2-carboxylate (186 mg, 0.55 mmol), isoamylamine (0.42 ml, 2.6 mmol), triethylamine (153 μl, 1.1 mmol) and HATU (209 mg, 0.55 mmol) were stirred at room temperature in 20 ml of DMF for 2 h. The solvent was evaporated off, and the residue was admixed with water and ethyl acetate. The organic phase was removed and concentrated, and the crude product was converted further directly. Yield: 225 mg, M+H+: 407.20.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003677B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-ea4888317de049ecb0939d0065e3da07 |
| Source note | uspto-grants-2011_08 |