2-(Trifluoromethyl)benzoyl chloride → HCID 25105791, compound

HRID 1675350Notes

Reaction equation

HRID 1675350 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[S:11][C:10]([N:12]3[CH2:19][C:18]4[CH2:17][NH:16][CH2:15][C:14]=4[CH2:13]3)=[N:9][CH:8]=2)=[O:6])[CH2:3][CH2:2]1.F[C:21](F)(F)C([O-])=O.[F:27][C:28]([F:39])([F:38])[C:29]1[CH:37]=[CH:36][CH:35]=[CH:34][C:30]=1[C:31](Cl)=[O:32]>>[CH:3]1([CH2:1][NH:4][C:5]([C:7]2[S:11][C:10]([N:12]3[CH2:13][C:14]4[CH2:15][N:16]([C:31](=[O:32])[C:30]5[CH:34]=[CH:35][CH:36]=[CH:37][C:29]=5[C:28]([F:39])([F:38])[F:27])[CH2:17][C:18]=4[CH2:19]3)=[N:9][CH:8]=2)=[O:6])[CH2:2][CH2:21]1

Participants

4

Reactant 3

HCID 675612-(Trifluoromethyl)benzoyl chlorideHCID 84468TrifluoroacetateHCID 67350785HCID 67350785, compound

Product 1

HCID 25105791HCID 25105791, compound

Procedure

N-(cyclopropyl)-2-(3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)thiazole-5-carboxamide, trifluoroacetate (106 mg, 0.26 mmol) was reacted with 2-trifluoromethylbenzoyl chloride analogously to example 3f. M+H+: 463.05.

Sources & evidence

ORD record
ord-ba57872374ff4c479c0f9d6f4999c44f
Source dataset
uspto-grants-2011_08
Patent number
US08003677B2

Reaction notes

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